Diseases That Start With S

Diseases That Start With S

Our post today takes a deep dive into the world of diseases that start with S.

Diseases are widespread medical conditions that can negatively impact the quality of life and potentially cause death. They can be infectious or non-infectious, acute or chronic, and are caused by a variety of factors ranging from lifestyle habits to environmental exposure. The symptoms of a disease can range from mild to severe and are unique depending on the illness. Effective diagnosis and management of diseases require a collaborative effort between the patient and medical practitioners, often involving careful monitoring, therapy, or surgery.

I approached the task of compiling a complete list of diseases that start with every alphabet with great enthusiasm and dedication. I committed myself to patiently studying and researching every possible ailment to ensure that my list was as comprehensive as possible, taking into account every medical terminology that I encountered during my research.

So, let’s begin exploring this list of diseases starting with S!


102 Diseases That Start With S

And here’s the list of diseases that begin with S letter.

Segmental neurofibromatosis

Segmental neurofibromatosis is characterized by the presence of neurofibromas or pigmented skin lesions on one area of the body. It is a rare form of neurofibromatosis and affects only a small portion of the population. The symptoms of segmental neurofibromatosis can vary widely, but generally, patients experience pain, itching, and even scarring. While there is no cure for this disease, treatments can help to alleviate the symptoms.

Sternal cleft

Sternal cleft is a rare congenital disorder that affects the development of the chest wall. It is caused by a failure of the embryonic sternum to fuse properly, leaving a gap in the chest. These gaps can range in size and may or may not cause serious health problems. Symptoms of sternal cleft often include difficulty breathing or infection in the chest cavity. Treatment usually involves surgical repair.


Salmonellosis is an infection caused by the bacteria Salmonella. It is transmitted through contaminated food or water and can cause diarrhea, fever, and abdominal cramping. Young children, elderly adults, and those with compromised immune systems are at the highest risk of developing severe symptoms. Most cases of salmonellosis do not require treatment, and patients typically recover within a few days. However, severe cases may require hospitalization.


Shingles, also known as herpes zoster, is a viral infection characterized by a painful rash. The virus that causes shingles is the same one that causes chickenpox. After a person recovers from chickenpox, the virus can remain dormant in the nervous system for years before reactivating as shingles. Symptoms of shingles include a painful, itchy rash that typically appears on one side of the body. Antiviral medications and pain relievers can help to alleviate symptoms.

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Seckel syndrome

Seckel syndrome is a rare genetic disorder that affects bone growth and development. The most common symptoms of Seckel syndrome include a small head, a beak-like nose, and microcephaly. Patients with Seckel syndrome may also experience developmental delays and intellectual disabilities. There is no cure for Seckel syndrome, but treatments can help to manage symptoms and improve quality of life.

Self-defeating personality disorder

Self-defeating personality disorder is a mental health disorder characterized by self-destructive behavior and negative thoughts. It is often associated with feelings of worthlessness and low self-esteem. Symptoms of self-defeating personality disorder can include chronic procrastination, self-sabotage, and a fear of success. Therapy and medication can help to manage symptoms and improve quality of life for those with this disorder.

Silvery hair syndrome

Silvery hair syndrome, also known as Griscelli syndrome, is a rare genetic disorder that affects pigmentation and immune function. The most common symptom of Silvery hair syndrome is silvery-gray hair that appears at an early age. Other symptoms of the syndrome may include immune system problems, developmental delays, and neurological issues. Treatment for Silvery hair syndrome is focused on managing symptoms.


SSADH, or succinic semialdehyde dehydrogenase deficiency, is a rare genetic disorder that affects the metabolism of neurotransmitters in the brain. The most common symptoms of SSADH include developmental delays, intellectual disabilities, and seizures. There is no cure for SSADH, but treatments can help to manage symptoms and improve quality of life for those with this disorder.


Septicemia, also known as sepsis, is a serious bacterial infection that can cause organ failure and death. Symptoms of septicemia can include fever, chills, rapid heartbeat, and rapid breathing. Treatment for septicemia usually involves hospitalization and antibiotics to fight the infection.

Sensory neuropathy

Sensory neuropathy is a condition that affects the nerves responsible for sensation, such as touch, temperature, and pain. Symptoms of sensory neuropathy can include numbness, tingling, burning, or prickling sensations in the affected areas. Causes of sensory neuropathy can include injury, infection, or certain medications. Treatment for sensory neuropathy depends on the underlying cause of the condition.

Schinzel syndrome

Schinzel syndrome is a rare genetic disorder that affects the development of multiple organ systems. Symptoms of Schinzel syndrome can vary widely, but may include abnormal facial features, heart defects, and developmental delays. There is no cure for Schinzel syndrome, but treatments can help to manage symptoms and improve quality of life.

Sly syndrome

Sly syndrome, also known as mucopolysaccharidosis type VII, is a rare genetic disorder that affects the metabolism of certain sugars in the body. The most common symptoms of Sly syndrome include skeletal abnormalities, developmental delays, and cognitive impairment. Treatment for Sly syndrome is focused on managing symptoms.

Shared psychotic disorder

Shared psychotic disorder, also known as folie a deux, is a mental health disorder in which two or more people have a delusional belief that is shared between them. One person in the relationship has a pre-existing psychotic disorder, while the other develops a shared delusion. Treatment for shared psychotic disorder usually involves therapy to help both parties manage symptoms.

Spirurida infections

Spirurida infections are caused by parasitic worms that live in the tissues of the human body. These infections are typically acquired through the ingestion of contaminated food or water. Symptoms of Spirurida infections can include fever, swelling, and pain in the affected area. Treatment for Spirurida infections typically includes medication to kill the parasites.

Seafood poisoning

Seafood poisoning can occur from eating contaminated seafood, including fish, shellfish, and crustaceans. Symptoms of seafood poisoning can include nausea, vomiting, and diarrhea. In severe cases, seafood poisoning can lead to hospitalization. Treatment for seafood poisoning usually involves supportive care to manage symptoms.

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Scurvy is a condition caused by a deficiency of vitamin C in the diet. Symptoms of scurvy can include fatigue, weakness, and bleeding gums. Severe cases of scurvy can lead to life-threatening complications. Treatment for scurvy involves increasing the amount of vitamin C in the diet through food or supplements.

Spondylometaphyseal dysplasia

Spondylometaphyseal dysplasia is a rare genetic disorder that affects bone growth and development. The most common symptoms of spondylometaphyseal dysplasia include short stature, abnormal curvature of the spine, and limb deformities. Treatment for spondylometaphyseal dysplasia is focused on managing symptoms and improving quality of life.

Spina bifida

Spina bifida is a congenital disorder that affects the spinal cord. Symptoms of spina bifida can include weakness or paralysis in the legs, hydrocephalus, and incontinence. Treatment for spina bifida usually involves surgery to close the opening in the spine and manage any associated symptoms.

Stomach cancer

Stomach cancer, also known as gastric cancer, is a cancer that affects the lining of the stomach. Symptoms of stomach cancer can include abdominal pain, nausea, and abnormal weight loss. Treatment for stomach cancer usually involves surgery to remove the tumor, along with chemotherapy and radiation therapy to prevent recurrence.

Syndrome X

Syndrome X, also known as metabolic syndrome, is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes. Symptoms of syndrome X can include high blood pressure, high cholesterol, and insulin resistance. Treatment for syndrome X usually involves lifestyle changes such as diet and exercise to manage the underlying conditions and reduce the risk of complications.

Spinal shock

A temporary loss of reflexes and paralysis following a spinal cord injury.


A rare parasitic infection characterized by itchy nodules on the skin and respiratory symptoms.

Swine influenza

A respiratory infection caused by the influenza virus that affects pigs but occasionally spreads to humans.


A brief loss of consciousness and muscle strength caused by a temporary drop in blood flow to the brain.

Syncopal tachyarythmia

A type of abnormal heart rhythm that can cause fainting.

Spirochetes disease

A bacterial infection caused by spirochetes, such as Lyme disease.

Strychnine poisoning

A potentially deadly condition caused by exposure to the poison strychnine, which affects the nervous system.


A rare genetic disorder that affects the pancreas, bone marrow, and skeletal system.

Salivary disorder

A condition that affects the production or flow of saliva, resulting in dry mouth or excessive drooling.


A rare but fatal complication of measles that affects the brain and nervous system.

Stomach flu

A viral infection that causes inflammation of the stomach and intestines, leading to nausea, vomiting, and diarrhea.

Stomach ulcers

Open sores that develop in the lining of the stomach, often caused by bacterial infection, stress, or certain medications.


A visual disorder in which the eyes do not align properly, leading to double vision, amblyopia, or other complications.

Spondyloepimetaphyseal dysplasia

A rare type of skeletal dysplasia that affects the growth and development of bones.

Specific phobia

An intense fear or anxiety related to a specific object, situation, or activity that is disproportionate to the actual threat posed.

Selective mutism

A social anxiety disorder in which a person is unable to speak in certain situations, such as school, work, or social gatherings.

Sixth nerve palsy

A condition that affects the sixth cranial nerve, leading to double vision, difficulty moving the eye, and other symptoms.

Sotos syndrome

A genetic disorder that causes physical overgrowth, delayed speech and motor development, and other cognitive and behavioral problems.

Septo-optic dysplasia

A rare congenital disorder that affects the development of the optic nerve, pituitary gland, and other structures in the brain.


A life-threatening condition that occurs when the body’s immune system overreacts to an infection, leading to widespread inflammation and organ damage.


A bacterial infection caused by Shigella species, which can cause diarrhea, fever, and abdominal cramps.

Sickle-cell anemia

An inherited blood disorder that affects the production of hemoglobin, leading to abnormal red blood cells, anemia, and other complications.


A fatal neurodegenerative disease that affects sheep and goats, causing abnormal behavior and coordination problems.

Septic shock

A life-threatening condition that occurs when sepsis progresses to dangerously low blood pressure and organ failure.

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Supranuclear ocular palsy

A neurological disorder that affects eye movements and can cause double vision, difficulty swallowing, and other symptoms.

Saito-Kuba-Tsuruta syndrome

A rare syndrome that primarily affects the nervous system.

Staphylococcus epidermidis infection

A type of bacteria that can cause infections in humans.

Satoyoshi syndrome

A rare multisystem disorder characterized by painful muscle spasms.


A type of genetic disease that affects the central nervous system.


An itchy skin condition caused by a tiny mite that burrows into the skin.

Short QT syndrome

A heart condition that can cause an abnormal heart rhythm.

Severe combined immunodeficiency

A rare disorder that affects the immune system.

Shprintzen syndrome

A genetic disorder characterized by abnormalities of the skeletal, cardiovascular, and connective tissue systems.


A rare genetic disorder that affects amino acid metabolism.

Sino-auricular heart block

A condition in which there is a disruption in the electrical signals that regulate the heartbeat.


A lung disease caused by exposure to silica particles.

Sea-blue histiocytosis

A rare disease that affects the metabolism of lipids.

Salla disease

A rare genetic disorder that affects the nervous system.


A group of inflammatory diseases that affect the spine and joints.

Subacute sclerosing leucoencephalitis

A rare neurological disease that affects the brain and spinal cord.


A painful lump on the eyelid that is caused by a bacterial infection.


A lung disease caused by exposure to iron particles.


A condition in which there is pain, numbness, or weakness in the lower back and legs.


A condition characterized by an abnormal curvature of the spine.

Schizoid personality disorder

A personality disorder characterized by a detachment from social relationships and a restricted range of emotional expression.


A disease in which small patches of inflamed cells form in different parts of the body.

Stromme syndrome

A rare genetic disorder that affects the development of multiple organ systems.

Sucrase-isomaltase deficiency

A genetic disorder that affects the ability to digest certain types of sugars.

Scarlet fever

A bacterial infection that causes a distinctive rash and high fever.

Secernentea Infections

A group of parasitic infections that can cause a range of health problems.

Scott syndrome

A rare bleeding disorder that affects blood clotting.


A disease caused by the variola virus that can cause fever, rash, and scarring.


A condition in which the spleen becomes enlarged.

Swyer syndrome

A rare genetic disorder that affects sexual development.

Shellfish poisoning

A type of food poisoning caused by consuming shellfish contaminated with certain toxins produced by algae.

Sleepwalking disorder

A sleep disorder where an individual can walk or perform other complex activities while still asleep.

Synovial sarcoma

A rare type of soft tissue cancer that usually affects the arms or legs of young adults.

Schimke syndrome

A rare genetic disorder that disturbs bone growth and immune system function.


A lung disease that occurs when silica dust is inhaled over a long period of time.


A progressive bone disease that causes increased bone density and thickness.

Separation anxiety disorder

An anxiety disorder that is commonly observed in children, where they experience excessive fear or distress when separated from their caregiver.


Sudden Infant Death Syndrome, a condition where an apparently healthy infant suddenly dies in their sleep, usually before their first birthday.

Spinal cord neoplasm

A rare tumor that grows inside the spinal cord or within its covering membranes.


A group of inherited metabolic disorders that affect the body’s ability to break down certain fats and lipids.


A sexually transmitted infection caused by the bacterium Treponema pallidum.


Saethre-Chotzen syndrome, a genetic disorder characterized by craniosynostosis (premature fusion of skull bones) and facial abnormalities.


Inflammation of the salivary glands, usually caused by a bacterial infection.

Schizotypal personality disorder

A personality disorder characterized by odd beliefs, behaviors, and speech patterns, but without the presence of delusions or hallucinations.


A group of inflammatory arthritis conditions that primarily affect the spine and joints.

Susac syndrome

A rare autoimmune disorder that causes damage to the small blood vessels in the brain, retina, and inner ear.


An inflammatory condition that affects the spinal joints and can cause chronic back pain and stiffness.

Saal Greenstein syndrome

A rare genetic disorder characterized by macular degeneration, optic nerve atrophy, and hearing loss.


A fungal infection that usually affects the skin and subcutaneous tissues, but can also affect the lungs, joints, and bones.

Spinocerebellar ataxia

A group of inherited degenerative disorders that affect the brain and spinal cord, resulting in problems with movement and coordination.

Sexually transmitted disease

A disease that spreads through sexual contact, including HIV, gonorrhea, chlamydia, syphilis, and herpes.


Severe Acute Respiratory Syndrome, a viral respiratory illness that first emerged in China in 2002.

Strudwick syndrome

A rare genetic disorder that affects bone development, causing short stature and abnormal bone shape.


An eating disorder characterized by a fear of food or aversion to food intake.


Adhesions or bands of scar tissue that can form between body tissues.

Strep throat

A bacterial infection of the throat that is typically characterized by a sore throat, fever, and swollen lymph nodes.

Santavuori disease

An inherited disorder that causes degeneration of the brain and nervous system, resulting in developmental delay, seizures, and blindness.

Wrapping Up

And that’s our list of S diseases.

Researching and categorizing medical conditions that start with every alphabet is a task that requires patience, diligence, and expertise. My approach was methodical, and I thoroughly scrutinized every medical term that I came across, categorizing the ailments systematically by the letter of the alphabet in which they belong.

After analyzing the various types of diseases, it is safe to say that they are one of the greatest challenges that humanity faces in present times. While we have made great strides in medical research, the incidence of diseases continues to grow. This calls for a more holistic approach towards tackling diseases, starting from prevention to providing innovative treatments.

Hope this post on diseases beginning with S alphabet has been useful to you!